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N-乙基-N-(3-磺丙基)-3-甲基本胺鈉鹽號：40567-80-4   
英文名稱：TOPS sodium salt；Sodium 3-(N-ethyl-3-methylanilino)propanesulfonate；3-(N-Ethyl-3-methylanilino)propanesulfonic acid sodium salt   
其他名稱：N-乙基-N-(3-磺丙基)間甲苯胺鈉鹽   
號：40567-80-4   
C12H18NNaO3S=279.33   
級別：試劑級   
含量：≥98%   
性狀(以下信息僅供參考)：白色結晶粉末。溶于水   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)酶光度法測定過氧化輕的水溶性試劑。   
保存：RT，避光。保質(zhì)期5年  客戶根據(jù)N-乙基-N-(3-磺丙基)-3-甲基本胺鈉鹽號：40567-80-4性質(zhì)、化學式、分子式、結構式、比重、密度、號、沸點、熔點、水溶性、MSDS、用途、作用、規(guī)格包裝、性狀、注意事項、英文名、別稱、純度、級別等情況，本產(chǎn)品化學性質(zhì)穩(wěn)定，運輸條件不苛刻，一般儲存在陰涼，干燥，通風良好的地方，遠離不相容的物質(zhì)。保持容器密閉。
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Subcellular Location : Nucleus, PML body. Cytoplasm. Note=Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm.
SirtT1 75 kDa fragment: Cytoplasm. Mitochondrion.
Tissue Specificity : Widely expressed.
Post-translational modifications : Methylated on multiple lysine residues; methylation is enhanced after DNA damage and is dispensable for deacetylase activity toward p53/TP53.
Phosphorylated. Phosphorylated by STK4/MST1, resulting in inhibition of SIRT1-mediated p53/TP53 deacetylation. Phosphorylation by MAPK8/JNK1 at Ser-27, Ser-47, and Thr-530 leads to increased nuclear localization and enzymatic activity. Phosphorylation at Thr-530 by DYRK1A and DYRK3 acivates deacetylase activity and promotes cell survival. Phosphorylation by mammalian target of rapamycin complex 1 (mTORC1) at Ser-47 inhibits deacetylation activity. Phosphorylated by CaMK2, leading to increased p53/TP53 and NF-kappa-B p65/RELA deacetylation activity (By similarity). Phosphorylation at Ser-27 implicating MAPK9 is linked to protein stability. There is some ambiguity for some phosphosites: Ser-159/Ser-162 and Thr-544/Ser-545.
Proteolytically cleaved by cathepsin B upon TNF-alpha treatment to yield catalytic inactive but stable SirtT1 75 kDa fragment (75SirT1).
S-nitrosylated by GAPDH, leading to inhibit the NAD-dependent protein deacetylase activity (By similarity).
Similarity : Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.
Database links : UniProtKB/Swiss-Prot: Q96EB6.2
在Sirtuin蛋白家族中，sirtuin 1參與多種新陳代謝活動，包括DNA的自我保護和修復，抑制脂質(zhì)過氧化積累，抑制其他細胞凋亡相關基因的表達以及和細胞壽命相關的活動。限制攝入的熱量可以加強SIRT1的表達，從而延長了壽命。
N-乙基-N-(3-磺丙基)-3-甲基本胺鈉鹽號：40567-80-4英文名稱  Anti-phospho-Src(Tyr418)
中文名稱  磷酸化Src原癌基因抗體
別    名  ASV; Avian sarcoma virus; c SRC; CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA; cSrc; EC 2.7.10.2; Neuronal CSRC tyrosine specific protein kinase; Neuronal SRC; Oncogene SRC; OTTHUMP00000030931; OTTHUMP00000174476; OTTHUMP00000174477; p60 Src; p60-Src; p60Src; pp60c src; pp60c-src; pp60csrc; Proto oncogene tyrosine protein kinase Src; Proto-oncogene c-Src; Proto-oncogene tyrosine-protein kinase Src; Protooncogene SRC; protooncogene SRC Rous sarcoma; Src; SRC Oncogene; SRC_HUMAN; SRC1; Tyrosine kinase pp60c src; Tyrosine protein kinase SRC 1; Tyrosine protein kinase SRC1; v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog; V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian); v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian; vsrc avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog.
濃    度  1mg/1ml
規(guī) 格  0.1ml/100μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat, Chicken, Pig, Sheep 
產(chǎn)品類型  一抗  磷酸化抗體  
研究領域  腫瘤 細胞生物 免疫學 染色質(zhì)和核信號 信號轉導 轉錄調(diào)節(jié)因子 激酶和磷酸酶 表觀遺傳學 
蛋白分子量  predicted molecular weight: 60kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated Synthesised phosphopeptide derived from mouse Src around the phosphorylation site of Tyr418
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Src (also known as pp60src) is a non receptor Tyrosine Kinase involved in signal transduction in many biological systems and implicated in the development of human tumors. There are two critical phosphorylation sites of tyrosine on Src, tyrosine 418 and tyrosine 529 (referring to human Src sequence). The tyrosine 418 is located in the catalytic domain and is one of the autophosphorylation sites. Full catalytic activity of Src requires phosphorylation of tyrosine 418. The tyrosine 529 is located near the carboxyl terminus of Src and acts as a negative regulator, in that Src is held in the inactive form