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天青II曙紅號：53092-85-6   
英文名稱：Azure II eosin；Azure II-Eosin mixture；Azur-Gemisch sicc. Giemsa Farbstoff   
其他名稱：Ⅱ號天青伊紅；天青曙紅   
號：53092-85-6   
級別：BS   
Maximum UV absorption：524～647nm   
性狀(以下信息僅供參考)：深綠色粉末。是*、天青II和曙紅的混合物。溶于乙醇、甲醇和甘油，微溶于水    
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)生物染色，配制姬姆薩氏色素   
保存：RT  客戶根據(jù)天青II曙紅號：53092-85-6性質(zhì)、化學(xué)式、分子式、結(jié)構(gòu)式、比重、密度、號、沸點(diǎn)、熔點(diǎn)、水溶性、MSDS、用途、作用、規(guī)格包裝、性狀、注意事項(xiàng)、英文名、別稱、純度、級別等情況，本產(chǎn)品化學(xué)性質(zhì)穩(wěn)定，運(yùn)輸條件不苛刻，一般儲存在陰涼，干燥，通風(fēng)良好的地方，遠(yuǎn)離不相容的物質(zhì)。保持容器密閉。
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級別：GR級別、AR級別、CP級別、L.P.級別等
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protein.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Rat
產(chǎn)品類型  一抗   
研究領(lǐng)域  腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 生長因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 
蛋白分子量  predicted molecular weight: 59kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human Nicalin (401-500aa)
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGF beta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype.
Function : May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.
Subunit : Forms a complex with NOMO2 and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex.
Subcellular Location : Endoplasmic reticulum membrane.
Tissue Specificity : Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
Similarity : Belongs to the nicastrin family.
Database links : UniProtKB/Swiss-Prot: Q969V3.2
Nicastrin(NCT)是高度糖基化的I型跨膜蛋白,是γ-分泌酶復(fù)合物的重要組件蛋白之一,廣泛分布于人類或鼠的所有細(xì)胞類型。它不僅與γ-分泌酶的組裝和成熟密切相關(guān),其構(gòu)象及表達(dá)變化對γ-分泌酶活性和阿爾茨海默病(Alzheimer's disease,AD)中β淀粉樣蛋白(amyloid proteinβ,Aβ)的產(chǎn)生及降解也起重要調(diào)節(jié)作用。
英文名稱  Anti-NKCC1
中文名稱  鈉鉀離子轉(zhuǎn)運(yùn)蛋白1抗體
別    名  Basolateral Na-K-Cl symporter; BSC; BSC2; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; mBSC2; NKCC1; S12A2_HUMAN; SLC12A2; sodium-potassium-chloride cotransporter 1; solute carrier family 12 (sodium/potassium/chloride transporters) member 2; Solute carrier family 12 member 2; sy-ns.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Rat, Chicken, Dog, Pig, Cow
產(chǎn)品類型  一抗   
研究領(lǐng)域  腫瘤 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 
蛋白分子量  predicted molecular weight: 133kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human NKCC1