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二甲苯藍(lán)FF號：4463-44-9   
英文名稱：Xylene cyanole FF；Xylene cyanol；Sodium salt of m′-hydroxydiethyldi-aminophenyl ditolylcarbinol disulfonic acid ；C.I. 43535   
其他名稱：二甲苯花黃FF；二甲苯磺酸；二甲苯苯胺   
號：4463-44-9    
C25H27N2NaO7S2=554.62   
級別：BR   
含量：≥80.0%   
吸光度試驗(yàn)：合格   
薄層層析試驗(yàn)：合格   
性狀(以下信息僅供參考)：藍(lán)綠色或藍(lán)黑色粉末。易溶于乙醇，溶于水溶液呈藍(lán)色，有刺激性   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)氧化還原指示劑(橙黃色～黃色)。生物染色劑，如組織培養(yǎng)中細(xì)胞活體染色。研究組織膜的滲透性。測定金屬鎳中微量鎂   
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schizophrenia. It regulates tracheal cell fates in the embryo and is necessary for the development of the posterior spiracles and the salivary gland duct. NPAS3 contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. Efficient DNA binding by NPAS2 requires dimerization with another bHLH protein.
Function : May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.
Subunit : Efficient DNA binding requires dimerization with another bHLH protein.
Subcellular Location : Nucleus.
Tissue Specificity : Ubiquitously expressed in the adult brain.
DISEASE : Note=A chromosomal aberration involving NPAS3 is found in a family with schizophrenia. Translocation t(9;14)(q34;q13).
Similarity : Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.
Database links : UniProtKB/Swiss-Prot: Q8IXF0.1
英文名稱  Anti-NPDC1
中文名稱  神經(jīng)細(xì)胞增殖和分化調(diào)控蛋白1抗體
別    名  AI314472; CAB1; Neural proliferation differentiation and control protein 1; NPDC-1; NPDC1; NPDC1_HUMAN.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Rat
產(chǎn)品類型  一抗   
研究領(lǐng)域  神經(jīng)生物學(xué) 細(xì)胞凋亡 細(xì)胞周期蛋白 細(xì)胞分化 
蛋白分子量  predicted molecular weight: 31kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human NPDC1
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 NPDC-1 (Neural Proliferation Differentiation and Control-1) is expressed in neurons once they have stopped dividing and begun to differentiate. NPDC-1 is transported from the Golgi apparatus via vesicles before becoming internalized by endosomes at the cell membrane. NPDC-1 interacts with Cdk2, D-type cyclins, and the transcription factor E2F1. This interaction can lead to an increased replication time, and might have implications in final neural differentiation and apoptosis. NPDC-1 has been shown to colocalize with synaptic vesicle proteins: synaptophysin, synaptobrevin 2, and Rab3 GEP (Rab3 GTP/GDP exchange protein). One function of NPDC-1 is to regulate retinoic acid-mediated events by directly interacting with retinoid receptors. The amino acid sequence of NPDC-1 is highly conserved between mouse, rat, and human.
Function : Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation.