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派洛寧B號(hào)：2150-48-3   
英文名稱：Pyronin B；［6-(Diethyl-amino)-3H-xanthen-3-ylidene］diethylammonium chloride；Tetraethyldiaminoxanthyl chloride；C.I. 45010     
其他名稱：吡羅紅B；焦寧B；哌羅寧B；化-3,6-雙(二乙氨基)呫噸；二苯癢雜芑胺B；二苯氧雜杞胺；派若寧B    
號(hào)：2150-48-3    
C42H54Cl8Fe2N4O2=1042.22   
級(jí)別：For microscopy   
有效分光含量Dye content：≥50.0%   
性狀(以下信息僅供參考)：化鐵絡(luò)合物為綠色有光澤結(jié)晶。溶于水，溶液呈紅色帶有黃色熒光。熔點(diǎn)176～178℃。Z大吸收波長(zhǎng) 555nm(Ｅ1％1cm2324)。   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)細(xì)菌、核糖核酸、粒線體和嗜堿細(xì)胞的染色。區(qū)分布魯氏桿菌的制菌劑   
保存：RT 
客戶根據(jù)派洛寧B號(hào)：2150-48-3 性質(zhì)、化學(xué)式、分子式、結(jié)構(gòu)式、比重、密度、號(hào)、沸點(diǎn)、熔點(diǎn)、水溶性、MSDS、用途、作用、規(guī)格包裝、性狀、注意事項(xiàng)、英文名、別稱、純度、級(jí)別等情況，本產(chǎn)品化學(xué)性質(zhì)穩(wěn)定，運(yùn)輸條件不苛刻，一般儲(chǔ)存在陰涼，干燥，通風(fēng)良好的地方，遠(yuǎn)離不相容的物質(zhì)。保持容器密閉。
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diagnostic applications.
產(chǎn)品介紹 Prenylation and methylation are two forms of protein modification, both of which are important for a variety of functions, including membrane attachment, protein-protein interactions and signaling events. NARF (nuclear prelamin A recognition factor), also known as IOP2, is a 456 amino acid nuclear protein that belongs to the NARF family. Expressed ubiquitously with highest expression in heart, skeletal muscle and brain, NARF binds to the C-terminal end of prenylated prelamin A and may be a member of a prelamin A-containing endoprotease complex. Additionally, via its association with prelamin A, NARF may be involved in heterochromatin organization. NARF is expressed as three isoforms due to alternative splicing events and, upon DNA damage, may be phosphorylated by ATM or ATR.
Function : Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.
Subunit : Interacts with LMNA and binds to the farnesylated C-terminal domain.
派洛寧B號(hào)：2150-48-3 Subcellular Location : Nuclear
Tissue Specificity : Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.
Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity : Belongs to the NARF family.
Database links : UniProtKB/Swiss-Prot: Q9UHQ1.1
英文名稱  Anti-NSMase2
中文名稱  中性鞘磷脂2抗體
別    名  N-SMase2; Cca1; neutral sphingomyelinase 2; Confluent 3Y1 cell-associated protein 1; Neutral sphingomyelinase 2; Neutral sphingomyelinase II; NSMA2_HUMAN; nSMase-2; nSMase2; Smpd3; Sphingomyelin phosphodiesterase 3.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來(lái)源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Rat, Dog, Pig, Cow, Rabbit
產(chǎn)品類型  一抗   
研究領(lǐng)域  細(xì)胞生物 神經(jīng)生物學(xué) 脂蛋白 
蛋白分子量  predicted molecular weight: 71kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human NSMase2
亞    型  IgG
純化方法  affinity purified by Protein A
儲(chǔ) 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.