“CD299抗體,Anti-DC-SIGNR/CD299抗體”應用于IHC、WB、 IF、IP、ELISA，質(zhì)量保證，無效免費退換，另外本公司生產(chǎn)經(jīng)營各種標記二抗、免疫印跡常用試劑、免疫組化常用試劑，咨詢！

產(chǎn)品介紹：

【產(chǎn)品名稱】：CD299抗體,Anti-DC-SIGNR/CD299抗體

【產(chǎn)品類型】：一抗

【產(chǎn)品編號】：BYk-2563R                    

【相關標記】: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647

【性 狀】： Lyophilized or Liquid

【濃 度】： 1mg/1ml

【亞 型】： IgG

【規(guī) 格】：0.1ml/100ug，0.2ml/200ug

【抗體來源】： Rabbit OR MOUSE

【克隆類型】： polyclonal or monoclonal

【產(chǎn)品用途】：科研實驗，用于免疫組化實驗，WB實驗、IF、IP、ELISA實驗，相應的標記抗體有HRP標記抗體，F(xiàn)ITC標記，BIO等。

【貯 存】： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

【信息詳情】： Dendritic cells （DC） play a primary role in the immune system as antigen presenting cells. A key molecule, dendritic cell specific ICAM3 grabbing nonintegrin （DC SIGN1）, is involved in regulating interactions between DC and resting T cells, including antigen presentation to T cells and enhancement of transinfection of CD4+ T cells by HIV 1. Efforts to identify additional type II membrane proteins resulted in the isolation of a related molecule named CD299, also known as DC SIGNR （DC SIGN Related）, DC SIGN2, CD209L, and L SIGN （liver/lymph nodespecific ICAM3 grabbing nonintegrin）. CD299 is located on Human chromosome 19p13.3 and shares 73-80% amino acid identity with DC SIGN1. Its structure is similar to DC SIGN1 and therefore binds mannose residues in a calcium dependent fashion, including ICAM3 and HIV 1 gp120. CD299 is polymorphic, since allelic variations of the exon 4 encoded sequence have been isolated. This is further supported by a study demonstrating the ability to isolate a large repertoire of CD299 transcripts largely the result of alternative splicing of the 7 coding exons.
CD299 is primarily transcribed in the liver and lymph nodes but not in monocyte derived DC. Expression of CD299 is restricted to endothelial cells derived from liver sinusoids, lymph nodes sinuses, and capillaries, although variable expression in placenta and some monocytic cell lines has also been reported, including both membrane and soluble isoforms of the protein.

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