环腺苷酸应答元件结合蛋白抗体,Anti-CREB-1抗体 返回列表页

“环腺苷酸应答元件结合蛋白抗体,Anti-CREB-1抗体”应用于IHC、WB、 IF、IP、ELISA，质量保证，无效免费退换，另外本公司生产经营各种标记二抗、免疫印迹常用试剂、免疫组化常用试剂，咨询！

产品介绍：

【产品名称】：环腺苷酸应答元件结合蛋白抗体,Anti-CREB-1抗体

【产品类型】：一抗

【产品编号】：BYk-0035M                    

【相关标记】: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647

【性 状】： Lyophilized or Liquid

【浓 度】： 1mg/1ml

【亚 型】： IgG

【规 格】：0.1ml/100ug，0.2ml/200ug

【抗体来源】： Rabbit OR MOUSE

【克隆类型】： polyclonal or monoclonal

【产品用途】：科研实验，用于免疫组化实验，WB实验、IF、IP、ELISA实验，相应的标记抗体有HRP标记抗体，FITC标记，BIO等。

【贮 存】： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

【详细信息】： Cyclic AMP Response Element Binding protein （CREB） is a basic / leucine zipper transcription factor that binds the cyclic AMP response element （CRE） and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein （CBP）, a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory. CREB knock out mice show diminished learning ability.

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