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Epibatidine is a high affinity agonist of nicotonic acetylcholine receptors and has also been shown to bind muscarinic receptors. These receptors are part of a group of acetylcholine G-protein coupled receptors (GPCRs) found in the central and peripheral nervous system that play a role in neuotransmission. Epibatidine functions as an analgesic at nicotinic receptors.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1102:

1. A. Lilja, O. Porras, E. Storelli, A. Nordberg, A. Marutle. Functional interactions of fibrillar and oligomeric amyloid-β with α7 nicotinic receptors in Alzheimer’s disease, In Journal of Alzheimer's disease, Volume 23, 2011, Pages 335-47.
2. A.V. Terry, D.A. Gearhart, S.P. Mahadik, S. Warsi, J.L. Waller, Chronic treatment with first or second generation antipsychotics in rodents: Effects on high affinity nicotinic and muscarinic acetylcholine receptors in the brain, In Neuroscience, Volume 140, Issue 4, 2006, Pages 1277-1287.