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目錄:珀金埃爾默企業(yè)管理(上海)有限公司>> (+/-)Epibatidine, [5,6-Bicycloheptyl-3H]-, 25µCi (925kBq)

(+/-)Epibatidine, [5,6-Bicycloheptyl-3H]-, 25µCi (925kBq)
  • (+/-)Epibatidine, [5,6-Bicycloheptyl-3H]-, 25µCi (925kBq)
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更新時間:2025-03-04 15:23:23瀏覽次數(shù):100評價

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(+/-)-Epibatidine radioligand tritiated at the 5,6-biocycloheptyl position. Epibatidine has analgesic activities, has been shown to function as an agonist at nicotinic acetylcholine receptors, and has......

Epibatidine is a high affinity agonist of nicotonic acetylcholine receptors and has also been shown to bind muscarinic receptors. These receptors are part of a group of acetylcholine G-protein coupled receptors (GPCRs) found in the central and peripheral nervous system that play a role in neuotransmission. Epibatidine functions as an analgesic at nicotinic receptors.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1102:

  1. A. Lilja, O. Porras, E. Storelli, A. Nordberg, A. Marutle. Functional interactions of fibrillar and oligomeric amyloid-β with α7 nicotinic receptors in Alzheimer’s disease, In Journal of Alzheimer's disease, Volume 23, 2011, Pages 335-47.
  2. A.V. Terry, D.A. Gearhart, S.P. Mahadik, S. Warsi, J.L. Waller, Chronic treatment with first or second generation antipsychotics in rodents: Effects on high affinity nicotinic and muscarinic acetylcholine receptors in the brain, In Neuroscience, Volume 140, Issue 4, 2006, Pages 1277-1287.

規(guī)格

濃度1.0 - 10 mCi/mL
檢測方法Radiometric
標簽位置Specifically Labeled
分子量208.7
產品品牌名稱NEN Radiochemicals
放射性同位素H-3
放射性核素3H
受體類型Nicotinic
運輸條件干冰
特殊訂購信息This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領域CNS & Neurologic, Pain, Inflammation
產品尺寸25 µCi

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