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目錄:珀金埃爾默企業(yè)管理(上海)有限公司>> Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) (DPDPE), 50µCi (1.85MBq)

Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) (DPDPE), 50µCi (1.85MBq)
  • Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) (DPDPE), 50µCi (1.85MBq)
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2-D-Penicillamine, 5-D-Penicillamine (DPDPE), tritiated on the tyrosyl group. Cyclic peptide, sequence: Tyr-D-Pen-Gly-Phe-D-Pen-OH. DPDPE is a synthetic enkephalin opioid peptide that acts as an agoni......

2-D-Penicillamine, 5-D-Penicillamine acts as a selective agonist at delta opioid receptors. These receptors are a suroup of GPCRs that are potential drug targets for pain and analgesia.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET922:

  1. Bunzow James R.,Saez Carmen,Mortrud Marty,Bouvier Claudia,Williams John T.,Low Malcolm and Grandy David K.(1994), Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type, FEBS Letters, 347.
  2. Weber SJ, Greene DL, Sharma SD, Yamamura HI, Kramer TH, Burks TF, Hruby VJ, Hersh LB, Davis TP (1991), Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration. J Pharmacol Exp Ther 259:1109–1117.

規(guī)格

濃度1.0 - 10 mCi/mL
檢測方法Radiometric
標(biāo)簽位置Specifically Labeled
分子量645.7
產(chǎn)品品牌名稱NEN Radiochemicals
放射性同位素H-3
放射性核素3H
運(yùn)輸條件干冰
特殊訂購信息This is a radioactive product - shipping address must have a license to receive radioactive materials.
產(chǎn)品尺寸50 µCi

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