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Mannitol is a sugar alcohol that is sometimes used as a sweetener due to its low glycemic index. It is produced by plants and fungi, and has been shown to play a role in fungal pathogenesis (Chaturvedi et al., Microbiology, 1996). Mannitol has more-recently been shown to help clear secretions in patients with cystic fibrosis (Nolan et al., Cochrane Database Syst Rev. 2015).