銆€銆€銆�鍎€琛�缍�(w菐ng) 鍎€琛ㄧ鏅�銆戜腑鍦嬬瀛�(xu茅)闄㈢悊鍖栨妧琛�(sh霉)鐮旂┒鎵€鐮旂┒鍝＄帇涔冭垐瑾查绲勮繎骞翠締鍦ㄧ┅(w臎n)瀹氬寲鍚堢墿鐨凜(sp3)-H閸靛畼鑳藉湗(tu谩n)鍖栧弽鎳�(y墨ng)鏂归潰鍙栧緱涓€绯诲垪閫�(j矛n)灞曪紝鐧�(f膩)灞曚簡鑻箼鐑垏閱�銆侀叜銆佽厛銆侀啔椤炵殑闆欏畼鑳藉湗(tu谩n)鍖栧弽鎳�(y墨ng)锛屽湪鏈夋(j墨)鍖栧(xu茅)鏍稿績鍒婄墿Org. Lett.绛夌櫦(f膩)琛ㄤ簡澶氱瘒鏂囩珷銆傝繎寰峰湅銆婂悎鎴愭湁姗�(j墨)鍖栧(xu茅)銆�(Synthesis, 2019, 51, 4531-4542)瑭曡堪浜嗛€欓爡(xi脿ng)宸ヤ綔锛屾妸涓婅堪涓€绯诲垪鎴愭灉绺界祼(ji茅)鎴愮偤涓€鍊�(g猫)鐜嬪弽鎳�(y墨ng)閫氬紡(Wang’s reaction)銆�
 

銆€銆€閱氭槸閱囨垨閰氱殑缇ュ熀涓殑姘鐑村熀鍙栦唬鐨勭敘(ch菐n)鐗�銆傞€氬紡鐐篟-O-R'锛孯鍜孯’鍙互鐩稿悓锛屼篃鍙互涓嶅悓銆傜浉鍚岃€呯ū鐐虹啊鍠啔鎴栬€呭彨灏嶇ū閱�;涓嶅悓鑰呯ū鐐烘贩鍚堥啔銆傚鏋淩銆丷'鍒嗗垾鏄竴鍊�(g猫)鏈夋(j墨)鍩哄湗(tu谩n)鍏╃鐨勭⒊鍘熷瓙鍓囩ū鐐虹挵(hu谩n)閱�锛屽鐠�(hu谩n)姘т箼鐑风瓑銆傚鏁�(sh霉)閱氬湪甯告韩涓嬬偤鐒¤壊娑查珨锛屾湁棣欏懗锛屾哺榛�(di菐n)浣�锛屾瘮姘磋紩锛屾€ц唱(zh矛)绌�(w臎n)瀹氥€傞啔椤炰竴鑸叿鏈夐夯閱変綔鐢�銆傚涔欓啔鏄嚚搴婂父鐢ㄧ殑鍚稿叆楹婚唹鍔戙€�
 

銆€銆€鐜嬩箖鑸堣椤岀祫鐮旂┒鐧�(f膩)鐝�(xi脿n)锛屽湪绋€鍦熷偓鍖栧姂Y(OTf)3鍌寲涓嬶紝浠ヤ簩鍙斾竵鍩洪亷姘у寲鐗╀綔鐐鸿嚜鐢卞熀寮曠櫦(f膩)鍔戯紝姘洔鑺崇兇鑸囬啔椤炲寲鍚堢墿鑳藉鐩存帴鐧�(f膩)鐢熷伓鑱�(li谩n)鍙嶆噳(y墨ng)锛岃┎鍙嶆噳(y墨ng)涔熷爆浜嶤(sp3)-H閸电殑瀹樿兘鍦�(tu谩n)鍖栫殑浜ゅ弶鑴矮鍋惰伅(li谩n)鍙嶆噳(y墨ng)(Cross-Dehydrogenative-Coupling, CDC)锛屽叿鏈夊師瀛愮稉(j墨ng)婵�(j矛)鎬уソ銆侀伕鎿囨€у挤(qi谩ng)绛夊劒(y艒u)鍕�銆�
 

銆€銆€鍋惰伅(li谩n)鍙嶆噳(y墨ng)鐐烘槸2A-B→A-A椤炲瀷鐨勫弽鎳�(y墨ng)銆傛槸鐢卞叐鍊�(g猫)鏈夋(j墨)鍖栧(xu茅)鍠綅閫�(j矛n)琛屾煇绋寲瀛�(xu茅)鍙嶆噳(y墨ng)鑰屽緱鍒颁竴鍊�(g猫)鏈夋(j墨)鍒嗗瓙鐨勯亷绋�銆傚伓鑱�(li谩n)鍙嶆噳(y墨ng)鍏锋湁澶氱ó閫斿緫锛屽湪鏈夋(j墨)鍚堟垚涓噳(y墨ng)鐢ㄦ瘮杓冨唬娉�銆傛皑鍩洪吀绲�(ji茅)鍚堣€屾垚铔嬬櫧璩�(zh矛)鐨勫弽鎳�(y墨ng)涔熸槸鍋惰伅(li谩n)鍙嶆噳(y墨ng)銆傚湪鏈夋(j墨)鍒嗘瀽涓�锛屽父鍒╃敤鍋惰伅(li谩n)鍙嶆噳(y墨ng)鐢�(ch菐n)鐢熺殑椤忚壊渚嗛憭瀹氬叿鏈夎嫰閰氭垨鑺宠兒绲�(ji茅)妲�(g貌u)鐨勮棩鐗�銆�
 

銆€銆€鍦ㄩ€欏€�(g猫)鍙嶆噳(y墨ng)鐮旂┒涓紝鐧�(f膩)鐝�(xi脿n)绋€鍦熷偓鍖栧姂Y(OTf)3鐨勫偓鍖栨晥鏋滄瘮Cu(OAc)2绛夊偓鍖栧姂濂�銆傜█鍦熷寲鍚堢墿涓殑鍖栧(xu茅)閸典互闆㈠瓙閸电偤涓�锛屽悓鏅�(sh铆)鍏锋湁涓€瀹氱殑鍏卞児(ji脿)鎬�锛�4f杌岄亾鐢变簬妤靛挤(qi谩ng)鐨勫睆钄戒綔鐢ㄨ€屼笉鍙冭垏鎴愰嵉銆傜█鍦熼嚁闆㈠瓙灞簬纭琇ewis閰�锛屽皪鍚爱鍘熷瓙鎴栬€呮哀鍘熷瓙鐨勫寲鍚堢墿鍏锋湁寰堝挤(qi谩ng)鐨勯厤浣嶈兘鍔涖€傛爱闆滆姵鐑村拰閱氳閲旈洟瀛愰厤浣嶅舰鎴愭椿鎬ч亷娓℃厠(t脿i)锛屼娇鍙嶆噳(y墨ng)瀹规槗閫�(j矛n)琛�銆傝┎鍙嶆噳(y墨ng)搴曠墿閬╃敤鑼冨湇寤�锛屾爱闆滆姵鐑磋垏閱氶倓鏈夌～閱氬潎鑳藉緱鍒癈(sp3)-H閸电殑瀹樿兘鍦�(tu谩n)鍖栫敘(ch菐n)鐗�銆傞櫎閺堥啔浠ュ锛岀挵(hu谩n)閱氫篃鍙互鏈夋晥鍦扮櫦(f膩)鐢烠(sp3)-H閸电殑瀹樿兘鍦�(tu谩n)鍖栧弽鎳�(y墨ng)銆傛墍寰楃殑31鍊�(g猫)鍙嶆噳(y墨ng)鐢�(ch菐n)鐗╅兘閫�(j矛n)琛屼簡鏍哥鍏辨尟姘瓬銆佺⒊璀滃強楂樺垎杈ㄨ唱(zh矛)璀滅殑琛ㄥ緛銆�
 

銆€銆€鏍哥鍏辨尟姘瓬(涔熺ū姘瓬) 鏄竴绋皣鍒嗗瓙涓矮-1鐨勬牳纾佸叡鎸晥鎳�(y墨ng)楂旂従(xi脿n)浜庢牳纾佸叡鎸尝璀滄硶涓殑鎳�(y墨ng)鐢�銆傚彲鐢ㄤ締纰哄畾鍒嗗瓙绲�(ji茅)妲�(g貌u)銆傜暥(d膩ng)妯ｅ搧涓惈鏈夋矮锛岀壒鍒ユ槸鍚屼綅绱犳矮-1鐨勬檪(sh铆)鍊�锛屾牳纾佸叡鎸矮璀滃彲琚敤渚嗙⒑瀹氬垎瀛愮殑绲�(ji茅)妲�(g貌u)銆傛矮-1鍘熷瓙涔熻绋变箣鐐烘皶銆�
 

銆€銆€姗�(j墨)鐞嗙爺绌舵柟闈紝浠栧€戜娇鐢ㄦ父闆㈠熀鎹曠嵅鍔慣EMPO閫�(j矛n)琛屼簡鎶戝埗瑭﹂(y脿n)锛岀祼(ji茅)鏋滅櫦(f膩)鐝�(xi脿n)鎹曠嵅鍔戠殑鍔犲叆鏈冧娇瑭插弽鎳�(y墨ng)鐚濇粎鑰岀劇鐩(bi膩o)鐢�(ch菐n)鐗╃敓鎴�锛屽苟鎴愬姛鍦扮敤楂樺垎杈ㄨ唱(zh矛)璀滄娓埌浜嗘崟鐛插姂TEMPO鑸囨父闆㈠熀褰㈡垚鐨勫姞鍚堢墿锛岃鏄庢鍙嶆噳(y墨ng)鐐烘父闆㈠熀姝风▼銆�
 

銆€銆€娓搁洟鍩烘崟鐛插姂鏄竴椤炲叿鏈夌┖闁撲綅闃绘晥鎳�(y墨ng)鐨勫搶鍟惰鐢熺墿椤炲厜绌�(w臎n)瀹氬姂锛屼富瑕佺偤鍙楅樆鑳洪,鍏剁┅(w臎n)瀹氭晥鑳芥瘮涓婅堪鐨勫厜绌�(w臎n)瀹氬姂楂樺咕鍊�,鏄叕瑾�(r猫n)鐨勯珮鏁堝厜绌�(w臎n)瀹氬姂銆傚姞鍏ラ珮鍒嗗瓙鏉愭枡涓兘鎶戝埗鎴栨笡绶╁厜姘у寲閬庣▼鐨勭墿璩�(zh矛)绋卞厜绌�(w臎n)瀹氬姂鎴栫传澶栧厜绌�(w臎n)瀹氬姂銆傚父鐢ㄧ殑鍏夌┅(w臎n)瀹氬姂鏍规摎(j霉)鍏剁┅(w臎n)瀹氭(j墨)鐞嗙殑涓嶅悓鍙垎鐐虹传澶栫窔鍚告敹鍔戙€佸厜灞忚斀鍔戝拰绱绶氱対婊呭姂銆佹父闆㈠熀鎹曠嵅鍔戠瓑銆�
 

銆€銆€瑾查绲勯倓閫氶亷姘樹唬鍥涙矮鍛嬪杻(THF-d8)鐨勫嫊鍔涘(xu茅)鍚屼綅绱犲(sh铆)椹�(y脿n)锛屾垚鍔熷湴椹�(y脿n)璀変簡α-C(sp3)-H閸电殑鏂疯鏄┎鍙嶆噳(y墨ng)鐨勯€熺巼姹哄畾姝ラ銆�
 

銆€銆€璩囨枡渚嗘簮锛氱悊鍖栨妧琛�(sh霉)鐮旂┒鎵€銆佺櫨搴�鐧剧